In this installment, the daughter of a Hong Kong tech executive goes missing in what appears to be a routine ransom job. As Breslin (Stallone) and his crew delve deeper, they discover the culprit is the deranged son of his former business partner, who also kidnapped the woman in Breslin's life, and is holding her inside the massive prison known as Devil’s Station.

Miami detectives Mike Lowrey and Marcus Burnett must face off against a mother-and-son pair of drug lords who wreak vengeful havoc on their city.

A group of Iraq War veterans look to clear their name with the U.S. Military, who suspect the four men of committing a crime for which they were framed.

At CERN, Father Silvano and Dr. Vittoria Vetra create three canisters of antimatter. Silvano is murdered, and one of the canisters is stolen. The Roman Catholic Church mourn the sudden death of Pope Pius XVI, and prepare for the papal conclave to elect his successor in Vatican City. Father Patrick McKenna, the Camerlengo of the Holy Roman Church, takes control of the Vatican. Four of the “preferiti”, the favoured candidates to be Pope, are kidnapped by a man claiming to represent the Illuminati. He sends the Vatican a warning, claiming he will murder each of the cardinals from 8pm to midnight, where the stolen antimatter will explode and destroy the city, hidden somewhere within.